Charitable expenditure £1.916 billion in 2024-25 — up 20% from £1.58bn; £5.2bn spent since 2022 toward £16bn decade plan (2022-2032)
Key Metric 1
711 grants awarded worth £1.3bn from 4,289 applications; 2,723 active grants at 1,443 organisations across 133 countries with total active value of £7.3bn
Key Metric 2
Investment portfolio grew to £39.9bn (10.2% total return, 6.4% after inflation); total funds £35.7bn; spending rise driven by renewals of Malawi-Liverpool-Wellcome, Mahidol Oxford Research Unit and co-funding of UK Health Data Research Service
Key Metric 3
First healthy babies born in UK through mitochondrial donation — Wellcome funded research, public engagement that changed UK law, and clinical trial; new oral antibiotic for plague found as effective as injection in Madagascar trials; digital interventions for mental health led in UK